期刊
NEUROSCIENCE LETTERS
卷 326, 期 1, 页码 5-8出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(02)00297-5
关键词
alpha-synuclein; endothelial cells; smooth muscle cells; amyloid beta; non-amyloid beta component; precursor of non-amyloid beta component; Parkinson's disease; Alzheimer's disease
The non-amyloid beta component of Alzheimer's disease amyloid (NAC) is detected in cerebral amyloid angiopathy; and the precursor of NAC is now known to be identical to alpha-synuclein (alpha-S), a major component of Lewy bodies in Parkinson's disease. We studied if cerebral vascular cells express alpha-S. Immunohistochemical studies of human cerebral tissues from control and cerebral amyloid angiopathy patients revealed the expression of alpha-S in vascular endothelial and smooth muscle cells. Then we studied the expression of alpha-S in vitro using cultures of vascular cells. Cultures of human umbilical vein endothelial cells and umbilical artery smooth muscle cells were found to constitutively express alpha-S messenger RNA and protein. alpha-S is normally expressed in vascular cells and may play some physiological role in the vascular wall. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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