期刊
SCIENCE
卷 296, 期 5576, 页码 2183-2185出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1072029
关键词
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资金
- NICHD NIH HHS [U54 HD-29125, HD-16580] Funding Source: Medline
Fertilization is the sum of the cellular mechanisms that pass the genome from one generation to the next and initiate development of a new organism. A typical, ovulated mammalian egg is enclosed by two layers: an outer layer of similar to5000 cumulus cells and an inner, thick extracellular matrix, the zona pellucida. To reach the egg plasma membrane, sperm must penetrate both layers in steps requiring sperm motility, sperm surface enzymes, and probably sperm-secreted enzymes. Sperm also bind transiently to the egg zona pellucida and the egg plasma membrane and then fuse. Signaling in the sperm is induced by sperm adhesion to the zona pellucida, and signaling in the egg by gamete fusion. The gamete molecules and molecular interactions with essential roles in these events are gradually being discovered.
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