期刊
MEDICINA CLINICA
卷 119, 期 4, 页码 121-124出版社
ELSEVIER ESPANA SLU
DOI: 10.1016/S0025-7753(02)73339-3
关键词
sildenafil; erectile dysfunction; sexual side effects of diabetes; quality of life; clinical trials; treatment
BACKGROUND: Erectile dysfunction is a common complication in patients with diabetes mellitus, which impairs quality of life, decreases self-esteem and can affect partners relationships. Sildenafil improves nitric oxide-dependent relaxation of smooth muscle in corpora cavernosa-induced by an increase in cGMP via inhibition of phosphodiesterase 5. PATIENTS AND METHOD: Multicenter, randomized double-blind, placebo-controlled study with flexible doses of sildenafil. The study was performed in 16 centers and recruited a total of 112 subjects with diabetes mellitus who had erectile dysfunction. At he start and end of the study, the following questionnaires were administered: international Index of Erectile Function (IIEF), Global Efficacy Assessment Question and Quality of Life Questionnaire (Fugi-Meyer). Of the 112 initially recruited patients, 92 received treatment, sildenafil in 44 and placebo in 48. RESULTS: A clear improvement was observed in the capacity to achieve and maintain an erection; 55.3% diabetic patients receiving sildenafil had at least one successful sexual intercourse (15.6% in the placebo group). In addition, significant improvements were seen in other aspects of the sexual activity of treated subjects. Among those treated with sildenafil, 46.3% reported a clear improvement of erections as compared to their baseline conditions (i.e. prior to treatment) vs only 14.9% in the placebo group. The percentage of a successful intercourse clearly increased, from 6 to 49%. Sildenafil was well-tolerated. Side effects were mild and transient. CONCLUSIONS: Sildenafil is an effective, safe treatment for erectile dysfunction in diabetic patients.
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