期刊
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
卷 50, 期 7, 页码 993-996出版社
HISTOCHEMICAL SOC INC
DOI: 10.1177/002215540205000713
关键词
surfactant proteins; collectins; innate immunity
类别
资金
- NHLBI NIH HHS [HL58047, HL24075] Funding Source: Medline
Surfactant proteins A and D, collagen-like lectins (collectins), were first isolated from the lung. In the lung, SP-A and SP-D have roles in surfactant homeostasis and innate immunity. In this study we show that SP-A and SP-D mRNA can be detected in a significant number of non-pulmonary tissues but the proteins have a more limited distribution. SP-D protein was detected in lung, uterus, ovary, and lacrimal gland, whereas SP-A protein was detected only in the lung. The results suggest that SP-D participates in mucosal immunity throughout the body.
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