期刊
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
卷 17, 期 7, 页码 664-669出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/gps.685
关键词
aging; magnetic resonance imaging; white matter hyperintensities; implicit learning; sequence learning; serial reaction time
资金
- NIA NIH HHS [P50-AG05133, R01-AG14051] Funding Source: Medline
- NIMH NIH HHS [P30-MH52247, T32-MH19986] Funding Source: Medline
Objective This study examined whether MRI evidence of cerebrovascular disease in the form of white matter hyperintensities (WMH) was associated with decreased implicit sequence learning performance in a high-functioning group of normal elderly volunteers. Method One hundred and eight community-dwelling elderly individuals received an MRI and performed an implicit sequence learning task, the serial reaction time (SRT) task. Results Hyperintensities present in the white matter were associated with a decreased learning effect. This association was found with both deep white matter and periventricular changes. Other factors affecting SRT performance (i.e., baseline reaction time and switch-cost) were not significantly related to the presence of WMH. Conclusions The results indicate that in addition to previously identified generalized cognitive deficits, WMH are also associated with a specific decrease in the implicit learning of sequences. Copyright (C) 2002 John Wiley Sons, Ltd.
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