期刊
MICROBES AND INFECTION
卷 4, 期 9, 页码 903-914出版社
ELSEVIER
DOI: 10.1016/S1286-4579(02)01613-1
关键词
Toll-like receptors (TLR); CD14; lipopolysaccharide (LPS); signal transduction; macrophage; endotoxin tolerance; septic shock; inflammation; cytokines
资金
- NIAID NIH HHS [AI-18797, AI-44936] Funding Source: Medline
This review will focus on the molecular mechanisms of macrophage activation and desensitization by bacterial lipopolysaccharide (LPS). The most recent advances in the understanding of the function of the LPS receptor complex and its role in the development of the septic shock syndrome and endotoxin tolerance will be discussed. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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