Studies on the efficacy of cholecalciferol and derivatives for stimulating phytate utilization in broilers

Studies were conducted to determine the effect of dietary supplementation with cholecalciferol (D-3), 1,25-dihydroxycholecalciferol [1,25-(OH)(2)D-3], 1(1alpha-hydroxycholecalciferol (1alpha-OHD3), and 25-hydroxycholecalciferol (25-OHD3) on utilization of phytate P by broiler chickens. Three experiments were conducted with corn-soybean meal type diets with D-3 and 1,25-(OH)(2)D-3 being tested in one experiment and 1,25-(OH)(2)D-3, 1alphaOHD(3), and 25-OHD3 being tested in two experiments of exactly the same design. In the first experiment, high levels of D-3 (110 mug and 220 mug/kg of diet) increased phytate P utilization, but the increase was not as great as that obtained from 1,25-(OH)(2)D-3 supplementation. In the other two experiments, 1,25-(OH)(2)D-3, D-3 and 1alpha-OHD3 were consistently effective in increasing phytate P utilization as measured by plasma Ca and P, incidence of P rickets, bone ash, and retention of Ca, P, and phytate P. Supplementation with 25-OHD3 in general gave smaller and more inconsistent responses to these criteria, indicating some inconsistency in its ability to improve phytate P utilization.