期刊
BIOMATERIALS
卷 23, 期 13, 页码 2649-2657出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0142-9612(01)00405-7
关键词
poly(3-hydroxybutyrate) (PHB); gastrointestinal patch; polymer degradation; enzymatic catalysis
For the development of a resorbable gastrointestinal patch. the in vitro degradation of solution-cast films of poly(3-hydroxybutyrate) (PHB), modifications of PHB expected to influence its degradation time, as well a poly(L-lactide) (PLLA) was examined. The Molecular, eight of pure PHB decreased by one-half after 1 year in buffer solution (pH 7.4, 37 degreesC). Acceleration in molecular, eight decrease was observed by blending with atactic PHB. Whereas no influence was found with low-molecular weight PHB. Leaching of a water-soluble additive led to a slight acceleration of PHB degradability. In contrast. a deceleration in degradation rate was observed with the addition of a hydrophobic plasticizer. In vitro tests indicated an accelerating effect of pancreatin on PHB degradation, whereas PLLA degradation remained essentially uninfluenced. In comparison to simple hydrolysis, the degradation rate of PHB was accelerated about threefold. From the in vitro results, a PHB atactic PHB blend was selected for repair of a bowel defect in Wistar rats. A patch film was fabricated by a dipping/leaching method. Twenty-six weeks post-implantation, material remnants were found in only one of four animals. The bowel defects ere closed in all cases. It Could be assessed that the patch material resists the intestinal secretions for a sufficiently long time but that it finally degrades completely. (C) 2002 Elsevier Science Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据