期刊
MOVEMENT DISORDERS
卷 17, 期 4, 页码 782-788出版社
WILEY-LISS
DOI: 10.1002/mds.10125
关键词
positron emission tomography; monosymptomatic resting tremor; Parkinson's disease
We sought to elucidate the relationship between monosymptomatic resting tremor (mRT) and Parkinson's disease (PD). We studied eight mRT patient,, (mean Hoehn and Yahr [HY], 1.1 +/- 0.4), eight patients with PD (mean HY, 1.5 +/- 0.8), who showed all three classic parkinsonian symptoms, and seven age-matched healthy subjects. Subjects underwent cerebral magnetic resonance imaging (MRI) and multitracer positron emission tomography (PET) with 6-[F-18]fluoro-L-dopa (F-dopa), [F-18]fluorodeoxyglucose (FDG), and [C-11]raclopride (RACLO). PD and mRT patients did not show significant differences in F-dopa-, RACLO-, or FDG-PET scans. In F-dopa- and RACLO-PET, significant differences between the pooled patient data and control subjects were found for the following regions: anterior and posterior putamen ipsilateral and contralateral to the more affected body side, and ipsilateral and contralateral putaminal gradients of the K-i values. Furthermore. we found a difference for the normalized glucose values of the whole cerebellum between the control group (0.94 +/- 0.06) and PD patients (1.01 +/- 0.04 P < 0.05) but not for the mRT group (0.97 +/- 0.03). Our findings indicate that monosymptomatic resting tremor represents a phenotype of Parkinson's disease, with a nearly identical striatal dopaminergic deficit and postsynaptic D2-receptor upregulation in both patient groups. We suggest that the cerebellar metabolic hyperactivity in PD is closer related to akinesia and rigidity rather than to tremor. (C) 2002 Movement Disorder Society.
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