期刊
JOURNAL OF CLINICAL EPIDEMIOLOGY
卷 55, 期 7, 页码 728-735出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0895-4356(02)00400-6
关键词
discontinuation; determinants; compliance; drug treatment; hypertension
Discontinuation of medication use constitutes a major barrier to adequate control of high blood pressure. We examined the effect of an array of potential predisposing, enabling and reinforcing factors on the discontinuation of newly prescribed antihypertensive medications. We conducted a prospective cohort study through a network of 173 pharmacies across Canada where were identified individuals newly prescribed an antihypertensive monotherapy. We interviewed participants by telephone four times to obtain information for a minimum duration of 18 months after entry into the cohort. We analyzed data using a multivariate proportional hazard model. Of 682 eligible participants, 43.3% had discontinued their initial medication at the end of the observation period. Individuals more likely to discontinue their initial medication were those who perceived side effects from this medication [Hazard Ratio (HR) = 1.91: 95% Confidence Interval (CI) 1.47-2.47). Individuals kith medication insurance coverage were less likely to discontinue (HR = 0.74: 95% CI 0.55-0.99). Persistence with newly prescribed medications could be improved by selecting antihypertensive medications containing fewer side effects and by lifting economic barrier, to drug treatment. (C) 2002 Elsevier Science Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据