期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 119, 期 5, 页码 508-516出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00334.2015
关键词
high-intensity interval training; prediabetes; aerobic exercise; glucose control; chronic inflammation
资金
- University of British Columbia
- Natural Sciences and Engineering Research Council of Canada Discovery Grant
Exercise can have anti-inflammatory effects in obesity, but the optimal type and intensity of exercise are not clear. This study compared short-term high-intensity interval training (HIIT) with moderate-intensity continuous training (MICT) in terms of improvement in cardiorespiratory fitness, markers of inflammation, and glucose control in previously inactive adults at elevated risk of developing type 2 diabetes. Thirty-nine inactive, overweight/obese adults (32 women) were randomly assigned to 10 sessions over 2 wk of progressive HIIT (n = 20, four to ten 1-min sessions at similar to 90% peak heart rate, 1-min rest periods) or MICT (n = 19, 20-50 min at similar to 65% peak heart rate). Before and 3 days after training, participants performed a peak O-2 uptake test, and fasting blood samples were obtained. Both HIIT (1.8 +/- 0.4 vs. 1.9 +/- 0.4 l/min, pre vs. post) and MICT (1.8 +/- 0.5 vs. 1.9 +/- 0.5 l/min, pre vs. post) improved peak O2 uptake (P < 0.001) and lowered plasma fructosamine (P < 0.05). Toll-like receptor (TLR) 4 (TLR4) expression was reduced on lymphocytes and monocytes after both HIIT and MICT (P < 0.05) and on neutrophils after MICT (P < 0.01). TLR2 on lymphocytes was reduced after HIIT and MICT (P < 0.05). Plasma inflammatory cytokines were unchanged after training in both groups, but MICT led to a reduction in fasting plasma glucose (P < 0.05, 5.9 +/- 1.0 vs. 5.6 +/- 1.0 mmol/l, pre vs. post). Ten days of either HIIT or MICT can improve cardiorespiratory fitness and glucose control and lead to reductions in TLR2 and TLR4 expression. MICT, which involved a longer duration of exercise, may be superior for reducing fasting glucose.
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