期刊
INFECTION AND IMMUNITY
卷 70, 期 7, 页码 3978-3981出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.70.7.3978-3981.2002
关键词
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资金
- NIGMS NIH HHS [T32 GM008347, GM08347] Funding Source: Medline
Staphylococcus aureus is a major cause of mastitis in bovine and other ruminant species. We here present the results of a comparative genomic analysis between a bovine mastitis-associated clone, RF122, and the recently sequenced human-associated clones, Mu50 and N315, of Staphylococcus aureus. A shotgun sequence survey of similar to10% of the RF122 genome identified numerous unique sequences and those with elevated rates of nonsynonymous substitution. Taken together, these analyses show that there are notable differences in the genomes of bovine mastitis-associated and human clones of S. aureus and provide a framework for the identification of specific factors associated with host specificity in this major human and animal pathogen.
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