期刊
JOURNAL OF LIPID RESEARCH
卷 43, 期 7, 页码 1125-1132出版社
ELSEVIER
DOI: 10.1194/jlr.M200060-JLR200
关键词
fatty acids; hypolipidemic drugs; electrospray ionization tandem mass spectrometry; hepatocyte nuclear factor-4 alpha
The profile of liver acyl-CoAs induced by dietary fats of variable compositions or by xenobiotic hypolipidemic amphipathic carboxylates was evaluated in vivo using a novel electrospray ionization tandem mass spectrometry methodology of high resolution, sensitivity, and reliability. The composition of liver fatty acyl-CoAs was found to reflect the composition of dietary fat. Treatment with hypolipidemic carboxylates resulted in liver dominant abundance of their respective acyl-CoAs accompanied by an increase in liver fatty acyl-CoAs. Cellular effects exerted by dietary fatty acids and/or xenobiotic carboxylic drugs may be transduced in vivo by their respective acyl-CoAs. Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry.
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