Association of ideal cardiovascular health metrics with serum uric acid, inflammation and atherogenic index of plasma: A population-based survey

Background and aims: We aimed to evaluate the link between inflammatory score [consisting of C-reactive protein ICRP) and white blood cells], serum uric acid ISUA) and atherogenic index of plasma IAIP) and the cardiovascular health ICVH) score. Methods: We used the cross-sectional National Health and Nutrition Examination Survey database. Statistical analyses accounted for the survey design and sample weights. Results: Overall, there were 23,004 participants Imean age=47.2 years, 46.5% males). Participants with an ideal CVH level had the highest ratio of poverty to income I3.62%, p < 0.001), as well as lower levels of CRP, SUA and AIP Ip < 0.001 for all comparisons). In adjusted linear regression, a significant negative association was observed between inflammatory score I beta=-0.052, p < 0.001), SUA I beta=-0.041, p < 0.001) and AIP I beta=-0.039, p < 0.001) and CVH score, i. e. participants with a better Igreater) CVH score had a lower inflammatory score. Results from adjusted logistic regression showed reduction in the likelihood of high-risk atherosclerosis Idefined as AIP =0.21) [intermediate: odds ratio IOR)=0.90, 95% confidence interval ICI): 0.85-0.95, ideal: OR=0.81, 95% CI: 0.74-0.88] and high CVD risk Idefined as CRP =3 mg/ l) [intermediate: OR=0.86, 95% CI: 0.73-0.98, ideal: OR=0.82, 95% CI: 0.69-0.95] across the categories of CVH. Conclusions: Our findings highlight that CVH metrics were associated with inflammatory score, SUA and AIP. Furthermore, participants with a better CVH score had a lower CVD risk. These results reinforce the importance of implementing healthy behaviours as proposed by the American Heart Association. If confirmed in clinical trials, this knowledge may have implications for CVD prevention and management.