期刊
ATHEROSCLEROSIS
卷 232, 期 1, 页码 134-140出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2013.10.026
关键词
Cohort study; Biomarkers; Intima-media thickness; Oxidation; Atherosclerosis; Ankle-brachial index
资金
- Instituto de Salud Carlos III FEDER-Fondo de Investigacion Sanitaria (FIS) [PI010105, PI081327, PI1101801]
- FEDER-Ministerio de Economia y Competitividad, Instituto de Salud Carlos III [Red HERACLES RD06/0009]
- MARATO TV3 [081630]
- Miguel Servet SNS contract [CP06/00100]
- Comissionat per la Universitat i Recerca, Departament d'Innovacio, Universitats i Empresa of the Generalitat de Catalunya, Agencia de gestio ajuts universitaris de recerca [AGAUR 2009 SGR 1195]
- Sociedad Espanola De Cardiologia [SEC 2010]
Objectives: To assess 1) the association of lipid oxidation biomarkers with 10-year coronary artery disease (CAD) events and subclinical atherosclerosis, and 2) the reclassification capacity of these biomarkers over Framingham-derived CAD risk functions, in a general population. Methods: Within the framework of the REGICOR study, 4782 individuals aged between 25 and 74 years were recruited in a population-based cohort study. Follow-up of the 4042 who met the eligibility criteria was carried out. Plasma, circulating oxidized low-density lipoprotein (oxLDL) and oxLDL antibodies (OLAB) were measured in a random sample of 2793 participants. End-points included fatal and non-fatal acute myocardial infarction (AMI) and angina. Carotid intima-media thickness (IMT) in the highest quintile and ankle-brachial index <0.9 were considered indicators of subclinical atherosclerosis. Results: Mean age was 50.0 (13.4) years, and 52.4% were women. There were 103 CAD events (34 myocardial infarction, 43 angina, 26 coronary deaths), and 306 subclinical atherosclerosis cases. Oxidized LDL was independently associated with higher incidence of CAD events (HR = 1.70; 95% Confidence Interval: 1.02-2.84), but not with subclinical atherosclerosis. The net classification index of the Framingham-derived CAD risk function was significantly improved when ox-LDL was included (NRI = 14.67% [4.90; 24.45], P = 0.003). No associations were found between OLAB and clinical or subclinical events. The reference values for oxLDL and OLAB are also provided (percentiles). Conclusions: OxLDL was independently associated with 10-year CAD events but not subclinical atherosclerosis in a general population, and improved the reclassification capacity of Framingham-derived CAD risk functions. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据