期刊
ATHEROSCLEROSIS
卷 237, 期 2, 页码 589-596出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2014.10.015
关键词
HDL; Small HDL; Atherosclerosis; Monocytes; Monocyte subsets; Inflammation
资金
- FWF Austrian Science Fund [SFB-54]
- Cellular Mediators Linking Inflammation and Thrombosis
- Association for the Promotion of Research on Arteriosclerosis, Thrombosis and Vascular Biology (ATVB)
- Ludwig Boltzmann Cluster for Cardiovascular Research
Objective: High-density lipoprotein (HDL) particles are heterogeneous in structure and function and the role of HDL subfractions in atherogenesis is not well understood. It has been suggested that small HDL may be dysfunctional in patients with coronary artery disease (CAD). Monocytes are considered to play a key role in atherosclerotic diseases. Circulating monocytes can be divided into three subtypes according to their surface expression of CD14 and CD16. Our aim was to examine whether monocyte subsets are associated with HDL subfractions in patients with atherosclerosis. Methods: We included 90 patients with angiographically stable CAD. Monocyte subsets were defined as classical monocytes (CD14++CD16; CM), intermediate monocytes (CD14++CD16+; IM) and non-classical monocytes (CD14+CD16++; NCM). HDL subfractions were measured by electrophoresis on polyacrylamide gel. Results: Serum levels of small HDL correlated with circulating pro-inflammatory NCM and showed an inverse relationship to circulating CM independently from other lipid parameters, risk factors, inflammatory parameters or statin treatment regime, respectively. IM were not associated with small HDL. In particular, patients with small HDL levels in the highest tertile showed dramatically increased levels of NCM (14.7 +/- 7% vs. 10.7 +/- 5% and 10.8 +/- 5%; p = 0.006) and a decreased proportion of CM (79.3 +/- 7% vs. 83.7 +/- 6% and 83.9 +/- 6%; p = 0.004) compared to patients in the two lower tertiles. In contrast, intermediate HDL, large HDL and total HDL were not associated with monocyte subset distribution. Conclusion: Small HDL levels are associated with pro-inflammatory NCM and inversely correlated with CM. This may suggest that small HDL could have dysfunctional anti-inflammatory properties in patients with established CAD. (C) 2014 The Authors. Published by Elsevier Ireland Ltd.
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