期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 2, 期 8, 页码 1213-1218出版社
ELSEVIER
DOI: 10.1016/S1567-5769(02)00078-4
关键词
non-steroid anti-inflammatory agents; microglia; inflammation; neurodegeneration
The anti-inflammatory agents are postulated to be effective in treating neurodegenerative disorders. in this study, we showed that indomethacin (IND) in the dose of 1 mg/kg protected neurons against toxic damage caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice model of Parkinson's disease. IND also diminished microglial activation and lymphocytic infiltration in the injured areas. These observations suggest that anti-inflammatory properties of IND may play a role in the neuron's protection in this model. However, diminished inflammatory reaction may be secondary to less neuronal damage.
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