期刊
DIABETOLOGIA
卷 45, 期 7, 页码 991-996出版社
SPRINGER
DOI: 10.1007/s00125-002-0865-y
关键词
diabetic pregnancy; offspring of diabetic mothers; foetal programming; cardiovascular disease
Aims/hypothesis. Maternal fuel metabolism is known to exert long range effects on the later development of children of diabetic mothers. Recently cardiovascular disease in adult life has been linked retrospectively with foetal malnutrition. The aim of this study was to identify whether markers for fuel-related cardiovascular programming exist for the offspring of diabetic pregnancy. Methods. Sixty-one children aged 5 to 11 years, of mothers with Type I (insulin-dependent) diabetes mellitus were compared with 57 randomly selected control children of non-diabetic mothers similar in age, sex and social class. Fasting blood was taken for plasma glucose, insulin, lipids, IGF-1, plasminogen activating inhibitor I (PAI-1) and the adhesion molecules ICAM-1, VCAM-1 and E-Selectin. Results. Fasting glucose and insulin were similar in the two groups. Differences existed between the off-spring of diabetic and non-diabetic pregnancies (mean +/- SD) for total cholesterol (4.45 +/- 0.56 vs 4.18 +/- 0.66, p=0.03), LDL cholesterol (2.73 +/- 0.49 vs 2.39 +/- 0.54, p=0.001), Cholesterol -to- HDL ratio (3.41 +/- 0.76 vs 3.09 0.73, p=0.03), IGF-1 (22.5 +/- 7.3 vs 19.3 +/- 8, p=0.04), PAI-1 (20.1 +/- 6.2 vs 14.9 +/- 7.3, p=0.000), VCAM-1 (1852 +/- 444 vs 1509 +/- 385, p=0.000) and E-Selectin (geometric mean; 83.1 vs 63.9, p=0.001). Conclusion/interpretation. These results indicate that important differences in cardiovascular risk factors exist between glucose-tolerant children of Type I diabetic and non-diabetic mothers, even in childhood. These data suggest that offspring of diabetic mothers might be at an increased risk for the development of vascular disease in later life.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据