期刊
MICROBES AND INFECTION
卷 4, 期 9, 页码 999-1006出版社
EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S1286-4579(02)01617-9
关键词
trypanosomes; GPI; VSG; TNF; pathology
African trypanosomes express a glycosylphosphatidyl inositol (GPI)-anchored variant-specific surface glycoprotein (VSG) as a protective coat. During infection, large amounts of VSG molecules are released into the circulation. Their interaction with various cells of the immune system underlies the severe infection-associated pathology. Recent results have shown that anti-GPI vaccination can prevent the occurrence of this pathology. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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