期刊
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
卷 132, 期 3, 页码 315-339出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S1532-0456(02)00094-7
关键词
marine; pharmacology; 1999; toxicology; review; secondary metabolites
资金
- NIAID NIH HHS [5KO2AI01502, 5R01AI36596] Funding Source: Medline
- NIEHS NIH HHS [R03-ES10138-01] Funding Source: Medline
This review, a sequel to the 1998 review, classifies 63 peer-reviewed articles on the basis of the reported preclinical pharmacological properties of marine chemicals derived from a diverse group of marine animals, algae, fungi and bacteria. In all, 21 marine chemicals demonstrated anthelmintic, antibacterial, anticoagulant, antifungal, antimalarial, antiplatelet, antituberculosis or antiviral activities. An additional 23 compounds had significant effects on the cardiovascular, sympathomimetic or the nervous system, as well as possessed anti-inflammatory, immunosuppressant or fibrinolytic effects. Finally, 22 marine compounds were reported to act on a variety of molecular targets, and thus could potentially contribute to several pharmacological classes. Thus, during 1999 pharmacological research with marine chemicals continued to contribute potentially novel chemical leads in the ongoing global search for therapeutic agents for the treatment of multiple disease categories. (C) 2002 Elsevier Science Inc. All rights reserved.
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