期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 13, 期 5, 页码 183-184出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S1043-2760(02)00610-0
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Efforts continue to dissect the neural basis of complex behaviors such as sex and aggression. A commonality in both these responses is the importance of olfaction. The opportunity presented by genetic ablation of a cation channel (TRP2), expressed selectively by the vomeronasal organ (principally involved in pheromone detection), has given rise to two independent Trp2(-/-) mouse strains. These knockout strains show a complete lack of male-male aggression and elevated sexual behavior that is directed at both males and females, an unpredicted and hitherto nonexistent behavioral phenotype in mice. Discerning a meaningful relationship between this phenotype and the neural basis of complex behaviors remains a challenge.
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