期刊
ATHEROSCLEROSIS
卷 234, 期 1, 页码 200-205出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2014.02.034
关键词
Bariatric surgery; Obesity; HDL; Oxidised LDL; Lipoprotein-associated phospholipase; A2 (Lp-PLA2); Weight loss
资金
- Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III, FIS [PI10/00277, PI11/01076, PI11/01159]
- Quality Research Group [2009-SGR-1205]
- Generalitat de Catalunya
- CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM)
- Instituto de Salud Carlos III
Objective: The purpose of this study was to evaluate the effect of weight loss induced in morbidly obese subjects by Roux-en-Y gastric bypass bariatric surgery on the atherogenic features of their plasma lipoproteins. Methods: Twenty-one morbidly obese subjects undergoing bariatric surgery were followed up for up to 1 year after surgery. Plasma and lipoproteins were assayed for chemical composition and lipoprotein-associated phospholipase A2 (Lp-PLA2) activity. Lipoprotein size was assessed by non-denaturing polyacrylamide gradient gel electrophoresis, and oxidised LDL by ELISA. Liver samples were assayed for mRNA abundance of oxidative markers. Results: Lipid profile analysis revealed a reduction in the plasma concentrations of cholesterol and tri-glycerides, which were mainly associated with a significant reduction in the plasma concentration of circulating apoB-containing lipoproteins rather than with changes in their relative chemical composition. All patients displayed a pattern A phenotype of LDL subfractions and a relative increase in the anti-atherogenic plasma HDL-2 subfraction (> 2-fold; P < 0.001). The switch towards predominantly larger HDL particles was due to an increase in their relative cholesteryl ester content. Excess weight loss also led to a significant decrease in the plasma concentration of oxidised LDL (similar to-25%; P < 0.01) and in the total Lp-PLA2 activity. Interestingly, the decrease in plasma Lp-PLA2 was mainly attributed to a decrease in the apoB-containing lipoprotein-bound Lp-PLA2. Conclusion: Our data indicate that the weight loss induced by bariatric surgery ameliorates the atherogenicity of plasma lipoproteins by reducing the apoB-containing Lp-PLA2 activity and oxidised LDL, as well as increasing the HDL-2 subfraction. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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