期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 2, 期 8, 页码 1205-1211出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1567-5769(02)00056-5
关键词
Agaricus blazei Murill; antibody production; mice
We investigated the inummopotentiating activities of boiled water-soluble extracts from desiccated Agaricus blazei Murill (ABM). Effect of ABM extract on antibody production was investigated by method of hemolytic plaque-forming cells (PFC) against sheep red blood cells (SRBC) antigen. ABM extracts significantly (p<0.01) increased the number of PFC in spleen with intraperitoneal administration at doses of 25 mg/kg as compared with control group. The populations of Mac-1- or CD25-positive cells significantly (p<0.01, p<0.00 1) increased, but in CD19-positive cells, there were no differences in ABM-treated mice as compared with control mice. The expressions of IL-6 and IL-1β mRNA were augmented by ABM extract in both peritoneal macrophages and spleen cells. These results suggested that ABM extract might be an effective stimulator for T cell and macrophage to IL-1β and IL-6 release, resulting in augmentation of antibody production against SRBC antigen.
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