期刊
INTERNATIONAL JOURNAL OF DERMATOLOGY
卷 41, 期 7, 页码 449-452出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-4362.2002.01543.x
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Tumor necrosis factor-alpha (TNF-alpha) is a chemokine secreted by T cells which is thought to play a critical role in the pathophysiology of psoriasis. The monoclonal antibody, infliximab, complexes with TNF-alpha, rendering it inactive. A recent clinical trial has reported the clinical benefit and safety of infliximab in moderate to severe plaque psoriasis. We report a case of rapid response and clinical benefit using infliximab in severe pustular psoriasis of von Zumbusch.
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