期刊
ATHEROSCLEROSIS
卷 230, 期 2, 页码 347-353出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2013.08.014
关键词
HDL size; LDL size; Nuts; Olive oil; PREDIMED; Small-dense LDL; Triglycerides; VLDL size
资金
- ISCIII (Spanish Ministry of Economy) [RTIC G03/140, RTIC RD 06/0045, FIS PS09/01292]
- Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain [CNIC 06/2007]
- ISCIII [CP 06/00100]
- Health Department of the Catalan Government (Generalitat de Catalunya) [CP 06/00100]
- California Walnut Commission, Sacramento, CA
- [FIS CD07/0083]
Objective: The PREDIMED trial showed that Mediterranean diets supplemented with either extra-virgin olive oil or nuts reduced incident cardiovascular events compared to a control diet. Consumption of both supplemental foods has been associated with reduced LDL-cholesterol, but it is unknown whether they can shift lipoprotein subfractions to a less atherogenic pattern. We investigated changes in adiposity and lipoprotein subfractions after consumption of the PREDIMED diets. Methods: In a PREDIMED sub-cohort (n = 169), lipoprotein subclasses (particle concentrations and size) were determined by nuclear magnetic resonance spectroscopy at baseline and after intervention for 1 year. Results: Participants allocated to the Mediterranean diet supplemented with nuts showed significant reductions from baseline of waist circumference (mean [95% CI]; -5 cm [-7; -3]) and concentrations of medium-small (-27 nmol/l [-46; -8]) and very small LDL (-111 nmol/l [-180; -42]); decreased LDL particle number (a nuclear magnetic resonance-specific measurement) (-98 nmol/l [-184; -11]); and an increase of large LDL concentrations (54 nmol/l [18; 90]), with a net increase (0.2 nmol/l [0.1; 0.4]) of LDL size. The Mediterranean diets with olive oil and nuts increased large HDL concentrations (0.6 mu M [0.0; 1.1] and 1.0 mu M [0.4; 1.5], respectively). Compared to the other two intervention groups, participants in the nut-enriched diet showed significantly reduced waist circumference (p <= 0.006, both) and increased LDL size (p < 0.05, both). Conclusion: Lipoprotein subfractions are shifted to a less atherogenic pattern by consumption of Mediterranean diets enriched with nuts. The results contribute mechanistic evidence for the reduction of cardiovascular events observed in the PREDIMED trial. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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