期刊
ATHEROSCLEROSIS
卷 225, 期 2, 页码 481-485出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2012.09.022
关键词
High density lipoprotein cholesterol; Carotid-femoral pulse wave velocity; Lecithin:cholesterol acyl transferase; Genetics; Intima media thickness; Magnetic resonance imaging
资金
- Merck Sharp and Dohme (MSD, USA)
- Dutch Heart Foundation [2008B070, 2010 T082]
- Netherlands Organisation for Scientific Research (NWO) [021.001.035]
- NWO [91612122, 91613031]
Objective: Carriers of a functional mutation in LCAT, encoding lecithin: cholesterol acyl transferase, are exposed to lifelong low high-density lipoprotein cholesterol (HDL-c) levels. We investigated whether LCAT mutation carriers have increased arterial stiffness as a marker of cardiovascular disease and whether arterial stiffness was associated with carotid wall thickening. Methods: We assessed 45 carriers of LCAT mutations (mean age +/- SD 46 +/- 13 yrs) and 45 age-matched controls. Probands referred with established cardiovascular disease were excluded. We measured carotid-fermoral pulse wave velocity (PWV) and carotid artery wall thickening by ultrasound and 3.0 T magnetic resonance imaging. Results: In carriers, HDL-c was lower (32 +/- 12 vs. 59 +/- 16 mg/dl; p < 0.0001) and triglycerides were higher (median 116 [IQR 80-170] vs. 71 [IQR 53-89] mg/dl; p < 0.001) vs. controls. PWV was higher in carriers vs. controls (7.9 +/- 2.0 m/s vs. 7.1 +/- 1.6 m/s; p < 0.01). This difference retained significance in multivariate analysis including age, sex, mean arterial pressure and body mass index, and after exclusion of carriers and controls with cardiovascular disease. Both in carriers and controls, PWV was correlated with wall thickening of the carotid arteries as assessed by ultrasound (R 0.50, p < 0.001 for carriers and R 0.36, p < 0.04 for controls) and 3.0 T magnetic resonance imaging (R 0.54, p < 0.001 for carriers and R 0.58, p < 0.001 for controls). Conclusion: Pulse wave velocity is increased in LCAT mutation carriers with low HDL-c and is associated with carotid wall thickening. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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