期刊
ATHEROSCLEROSIS
卷 218, 期 1, 页码 102-106出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2011.05.011
关键词
Anti-oxidative properties; High density lipoproteins; Skin autofluorescence; Type 2 diabetes mellitus
资金
- Dutch Diabetes Research Foundation
- Netherlands Organization for Scientific Research [917-56-358]
- GECKO
- Top Institute Food and Nutrition
Objective: High density lipoprotein (HDL) particles protect apolipoprotein B-containing lipoproteins from oxidative modification. An impaired anti-oxidative functionality of HDL in type 2 diabetes mellitus (T2DM) may contribute to enhanced formation of oxidative stress products, such as Advanced Glycation Endproducts (AGEs). We tested whether in T2DM the HDL anti-oxidative capacity is related to the accumulation of AGEs in the skin. Methods: Skin autofluorescence (AF), a non-invasive read-out for AGEs, and HDL anti-oxidative capacity, i.e. the ability of HDL to protect against LDL oxidation in vitro, were assessed in 67 non-smoking T2DM patients without complications (median age: 60 (53-65), 60% males, 6.5 (5.2-8.5) years of diabetes duration). Results: In univariate analysis, skin AF correlated inversely with HDL anti-oxidative capacity (r = -0.305, P < 0.02), but not with HDL cholesterol or apolipoprotein A-I. HDL anti-oxidative capacity correlated inversely with glucose, HbA(1c), triglycerides, and insulin resistance (homeostasis model assessment) (P < 0.05 to P <= 0.001). Multiple linear regression showed that skin AF remained inversely related to HDL anti-oxidative capacity (partial r = -0.314, P = 0.015) taking account of age, plasma glucose, non-HDL cholesterol, triglycerides, HOMA(ir), and CRP. Conclusion: These findings suggest that skin AF is inversely related to the HDL anti-oxidative capacity rather than to the HDL cholesterol concentration in T2DM. Impaired anti-oxidative functionality of HDL could contribute to tissue accumulation of AGEs. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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