期刊
ATHEROSCLEROSIS
卷 217, 期 1, 页码 249-252出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2011.03.020
关键词
Cardiovascular disease; Cholesteryl ester transfer; Cholesteryl ester transfer protein; Prospective nested case-control study
资金
- Netherlands Heart Foundation [2001.005]
Objective: The relationship of cardiovascular disease (CVD) with plasma cholesteryl ester transfer protein (CETP) levels is controversial. We determined whether plasma cholesteryl ester transfer (CET), reflecting CETP-mediated transfer of cholesteryl esters from endogenous HDL towards apolipoprotein B-lipoproteins, predicts incident CVD. Methods: A prospective nested case-control study was carried out in 114 men who developed CVD and 105 controls. Participants did not use lipid lowering drugs at baseline. Plasma CET was assayed using an isotope method. Results: Plasma CET was 19% higher (P = 0.030), whereas CETP mass was unaltered (P = 0.30) in cases vs. controls. Plasma CET predicted CVD (age-adjusted hazard ratio (HR): 1.20(95% CI 1.02-1.46, P = 0.028), but incident CVD was unrelated to CETP mass (HR: 0.88(95% CI 0.73-1.07), P = 0.20). Plasma CET still predicted CVD after additional adjustment for total cholesterol/HDL cholesterol, triglycerides and non-lipid risk markers (HR: 1.22(95% CI 1.02-1.46, P = 0.031). Conclusion: Plasma CET rather than CETP mass may be a determinant of cardiovascular risk. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据