期刊
JOURNAL OF PEDIATRICS
卷 141, 期 1, 页码 132-134出版社
MOSBY-ELSEVIER
DOI: 10.1067/mpd.2002.125226
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The expression of muscle membrane-associated neuronal nitric oxide synthase (NOS1) is significantly impaired in Duchenne muscular dystrophy. Mean (+/- SEM) exhaled NO in 13 male patients with Duchenne muscular dystrophy was significantly lower than in 11 healthy age-matched male control subjects (7.5 +/- 1.4 vs 16.6 +/- 3.2 parts per billion, P < .02) or 17 adult male control subjects (18.5 +/- 1.8 parts per billion, P < .001). These findings provide indirect evidence that NOS1 contributes significantly to fractional exhaled nitric oxide in healthy children. (J Pediatr 2002;141:132-4).
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