期刊
ATHEROSCLEROSIS
卷 210, 期 1, 页码 243-248出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2009.10.043
关键词
Intracerebral hemorrhage; Infarction; Cardiac; Risk factors in epidemiology; Cohort studies; Triglycerides
资金
- Fondation pour la Recherche Medicale
- Caisse Nationale Maladie des Travailleurs Salaries
- Direction Generale de la Sante
- MGEN
- Institut de la Longevite
- Conseils Regionaux of Aquitaine
- Bourgogne
- Fondation de France
- Ministry of Research
- INSERM
Background: Few studies have assessed the relationship between triglycerides and the risk of hemorrhagic stroke, which contrasts the considerable number of studies about triglycerides and ischemic vascular events. We analyzed the association pattern between triglycerides and incident intracerebral hemorrhage as compared with coronary events and ischemic stroke, in a large cohort of elderly. Methods: Population-based, prospective cohort study among 8393 men and women participating in the Three-City Study, aged >= 65 years at baseline. Fasting blood lipids, including triglycerides, were measured at baseline. Fatal and non-fatal strokes and coronary events were adjudicated and validated by scientific committees. Cox proportional hazards models were used to adjust for potential confounders. Results: During a mean follow-up of 5.0 years, 36 hemorrhagic strokes, 143 ischemic strokes, and 393 coronary events occurred. An increased level of triglycerides was associated with an increased risk of ischemic vascular events. Conversely, a low level of triglycerides (<= 0.94 mmol/L) was associated with an increased risk of hemorrhagic stroke (adjusted hazard ratio 2.35; 95% confidence interval 1.18-4.70). The relationship with hemorrhagic stroke was mainly apparent in men, in individuals with high blood pressure, and in those with low levels of cholesterol. Conclusions: In this large cohort of elderly men and women, low triglycerides levels were associated with an increased risk of hemorrhagic stroke and a decreased risk of ischemic vascular events. The association between triglycerides and hemorrhagic stroke was particularly strong in men, in subjects with high blood pressure and in those with low cholesterol levels. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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