期刊
TISSUE ANTIGENS
卷 60, 期 1, 页码 36-42出版社
WILEY
DOI: 10.1034/j.1399-0039.2002.600105.x
关键词
genetic susceptibility; IL-18; sarcoidosis; single nucleotide polymorphism
Interleukin-18 (IL-18) and interleukin-12 (IL-12) synergistically stimulate interferon-gamma (IFN-gamma) production from Th1 cells. The levels of serum IL-18 and IFN-gamma and bronchoalveolar lavage fluid IL-18 were elevated in patients with sarcoidosis. The polymorphisms of the IL-18 gene may play a possible role in expression regulation of the gene. We investigated the roles of the polymorphisms in the development of sarcoidosis. We examined two single nucleotide polymorphisms of the IL-18 gene in 119 patients with sarcoidosis and 130 healthy control subjects. Our results showed that the frequency of sarcoidosis patients with the CA genotype at position -607 was significantly higher than that with the AA genotype (OR=2.200) and a significantly higher proportion of patients had the C allele at -607 compared with that of the controls (OR=2.123). No significant differences were seen in the distribution of the genotypes or phenotype frequencies at position 137. There was no specific organ involvement associated with a certain genotype or phenotype. In IL-18 gene polymorphisms, the C allele at position -607 might be a genetic risk factor for sarcoidosis in this Japanese population.
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