期刊
ATHEROSCLEROSIS
卷 211, 期 2, 页码 531-538出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2010.03.026
关键词
CETP; Polymorphism; Cardiovascular risk; Alcohol
资金
- Spanish Ministry of Health [PI041224, PI042342, PI041822, PI042188]
- RETIC [RD06/0020]
- CIBER [OBN 06/03]
- CIBERESP
- Spanish Regional Government of Andalusia
- Spanish Regional Government of Asturias
- Spanish Regional Government of Basque Country
- Spanish Regional Government of Murcia
- Spanish Regional Government of Navarra
- Catalan Institute of Oncology
Objective: Despite the consistent association between cholesteryl ester transfer protein (CETP) gene variation and plasma HDL-C, huge controversy still rages on its association with coronary heart disease (CHD). We investigated the association between the CETP-TaqIB polymorphism, HDL-C and incident CHD in a Mediterranean population. Methods: A nested case-control study among participants of the Spanish EPIC cohort was performed. 41,440 healthy individuals (30-69 years) were followed up over a 10-year period, incident CHD cases being identified. We analyzed 557 confirmed CHD cases and 1180 healthy controls. Results: Despite B2B2 subjects having the highest HDL-C concentrations and B1B1, the lowest (P < 0.001), no protective effect of the B2 allele against CHD incidence was observed. Thus, in comparison with B1B1 subjects, the adjusted CHD risk of B1B2 was OR: 1.00, 95% CI: 0.80-1.26; P = 0.982, and that of B2B2 was OR: 1.16, 95% CI: 0.84-1.61; P = 0.374. These results did not change after adjustment for HDL-C. No significant interaction between alcohol consumption and the CETP-TaqIB polymorphism in determining HDL-C was found. However, a different effect of this polymorphism on CHD risk in drinkers and nondrinkers was observed. In non-drinkers, the B2B2 genotype was associated with a non-significant lower CHD risk, whereas in drinkers it was associated with a greater risk (OR: 1.55, 95% CI: 1.05-2.29; P = 0.026). We also observed that in diabetics (11% cases and 7.4% controls), the B2 allele was significantly associated with higher CHD risk. Conclusions: In this Mediterranean population, the CETP-TaqIB polymorphism was not associated with a lower CHD incidence, and its effect was modulated by alcohol and possibly by diabetes. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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