Phospholipase A(2)s: Developing drug targets for atherosclerosis

The potential for phospholipases as targets for treating atherogenesis has become more prominent over the past year with the publication of the results of Phase 2 clinical trials of two inhibitors of forms of phospholipase A(2): darapladib (GSK) which inhibits lipoprotein-associated phospholipase A(2) and varespladib (Anthera) an inhibitor of several secreted phospholipase A(2)s. Although some aspects of their biology overlap, these are distinct targets with different potential for influencing atherogenesis. The background science to these two targets is discussed in this review, noting the balance of data, from human, preclinical species and in vitro that support further development of the inhibitors into Phase 3. Note is taken of another phospholipase A(2) (cytosolic) which has been less fully described but for which there has been some interest. (C) 2010 Elsevier Ireland Ltd. All rights reserved.