期刊
ATHEROSCLEROSIS
卷 213, 期 1, 页码 251-255出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2010.02.041
关键词
Cholesterol; LDL; HDL; Coronary heart disease; Framingham Offspring Study
资金
- Kyowa Medex Co., Tokyo, Japan
- Denka Seiken Co., Tokyo, Japan
- National Institute of Health, Bethesda, MD [NHLBI N01-HC 25195, HL 60935]
- National Institutes of Health [R01 HL-60935, HL 74753, PO50HL083813]
- U.S. Department of Agriculture [58-1950-4-401]
Background: We evaluated direct low density lipoprotein (LDL) cholesterol (C) and high density lipoprotein (HDL) cholesterol (C) versus standard methods using fasting plasma samples from participants in cycle 6 of the Framingham Offspring Study. Methods: Direct LDL-C and HDL-C measurements were performed on fasting plasma from male (1335 controls, 173 CHD cases) and female (1606 controls, 74 cases) participants, and compared with LDL-C, as calculated with the Friedewald formula, and HDL-C, as measured after dextran-Mg(2+) precipitation. Results: Values for direct LDL-C and HDL-C correlated well with standard methods (both about r(2) = 0.94, p < 0.001) with similar absolute values. Biases of >10% were present for 7.7% of samples for LDL-C, while for HDL-C this value was 8.5%. Despite higher use of cholesterol-lowering medication in CHD cases, calculated or direct LDL-C values were still well above recommended values [<2.6 mmol/L (100 mg/dL)] in CHD cases, especially in females. Conclusions: Direct assays for both LDL-C and HDL-C provide an acceptable guide for lipid treatment. In Framingham Offspring Study participants most CHD cases had LDL-C levels above the recommended target. (C) 2010 Published by Elsevier Ireland Ltd.
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