期刊
MARINE BIOTECHNOLOGY
卷 4, 期 4, 页码 431-440出版社
SPRINGER-VERLAG
DOI: 10.1007/s10126-002-0004-2
关键词
N-substituted maleimides; N-substituted succinimides; in vitro antifouling activities; phenoloxidase inhibitors; marine fungi; marine bacteria
In the search for novel biodegradable antifouling agents, a series of imides (N-substituted maleimides and succinimides) have been synthesized. A large majority of N-substituted maleimides and succinimides showed an antimicrobial activity toward gram-positive and gram-negative bacteria and fungi of marine origin with minimal inhibition concentrations in the range of 6 to 24 mug/ml. The imides with an alkyl substituent showed higher activities than aromatic analogues, but structure-activity relationships were not clearly established. Some compounds were powerful inhibitors of Mytilus edulis phenoloxidase. This inhibition was noncompetitive as demonstrated with 2 maleimides, a 3-acetoxy succinimide and a succinimide. Thus, this family of products has potential interest as antifouling agents.
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