期刊
ATHEROSCLEROSIS
卷 202, 期 2, 页码 543-549出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2008.04.047
关键词
Neopterin; Antioxidants; Vitamins; Immune activation; Coronary artery disease (CAD); Oxidative stress
资金
- government of the State of the Austrian Tyrol
- Stiftung Propter Homines, Vaduz-Furstentum Liechtenstein
- Zukunftsfonds of the Government of Styria
Neopterin is released from human monocyte-derived macrophages upon stimulation with interferon-gamma and is a sensitive indicator for cellular immune activation. Furthermore, reactive oxygen species (ROS) are produced in case of immune activation and inflammation. In a cross-sectional approach, plasma concentrations of neopterin and of antioxidant compounds and vitamins were compared in 1463 patients investigated by coronary angiography, which were recruited within the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study. Serum neopterin concentrations were higher in patients with coronary artery disease (CAD; mean +/- S.D.: 8.7 +/- 7.3 nmol/L) compared to controls (7.4 +/- 5.0 nmol/L; Welch's t-test: p<0.001). Mean concentrations of ascorbic acid (p<0.0001), gamma-tocopherol (p<0.05), lycopene (p<0.001), lutein + zeaxanthin (p<0.05), a-carotene (p<0.05) and beta-carotene (p<0.05) were lower in CAD than in controls. Neopterin concentrations correlated with CAD-score (r(s)=0.156; p<0.0001) and inversely with antioxidants lycopene (r(s)=-0.277;p<0.0001) and lutein + zeaxanthin (r(s) =-0.175; p<0.0001) levels and with vitamins ascorbic acid (r(s)=-0.207; p<0.0001) and alpha-tocopherol (r(s)=-0.105; P<0.0001). The study demonstrates that higher neopterin production is associated with lower concentrations of antioxidant compounds in patients at risk for atherosclerosis. Results suggest that lower concentrations of antioxidant compounds may relate to higher grade of chronic immune activation in patients. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据