期刊
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卷 181, 期 1, 页码 81-85出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3835(02)00041-1
关键词
p73 dinucleotide polymorphism; p53 Arg72Pro polymorphism; esophageal cancer risks; stomach cancer risk; colorectal cancer risk; polymerase chain reaction with confronting two-pair primers
类别
A case-control study was conducted to examine the possible association between digestive tract cancers and p73 G4C14-to-A4TI4 at exon 2 and p53 Arg72Pro polymorphisms in Japanese. Cases were 102 esophageal cancer patients, 144 stomach cancer patients, and 147 colorectal cancer patients, and controls were 241 non-cancer outpatients. The genotype frequencies among controls were 55.3% for p73 GG at position 4, 40.4% for GA, and 4.3% for AA, and 37.7% for p53 ArgArg, 44.4% for ArgPro, and 18.0% for ProPro. No significant differences in the genotype frequencies were observed between the controls and each case group or case, as a whole. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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