期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 99, 期 14, 页码 9562-9567出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.132269699
关键词
-
资金
- NEI NIH HHS [EYK08-00403] Funding Source: Medline
- NIGMS NIH HHS [GM28755, R01 GM028755] Funding Source: Medline
- NINDS NIH HHS [R01 NS021749, NS-21749] Funding Source: Medline
We measured daily gene expression in heads of control and period mutant Drosophila by using oligonucleotide microarrays. In control flies, 72 genes showed diurnal rhythms in light-dark cycles; 22 of these also oscillated in free-running conditions. The period gene significantly influenced the expression levels of over 600 nonoscillating transcripts. Expression levels of several hundred genes also differed significantly between control flies kept in light-dark versus constant darkness but differed minimally between per(01) flies kept in the same two conditions. Thus, the period-dependent circadian clock regulates only a limited set of rhythmically expressed transcripts. Unexpectedly, period regulates basal and light-regulated gene expression to a very broad extent.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据