期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 99, 期 14, 页码 9352-9357出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.102291599
关键词
-
资金
- NHLBI NIH HHS [F32 HL010496, 5 F32 HL10496-02] Funding Source: Medline
- NIA NIH HHS [AG12288] Funding Source: Medline
The G(12) subfamily of heterotrimeric G-proteins consists of two members, G(12) and G(13). Gene-targeting studies have revealed a role for G(13) in blood vessel development. Mice lacking the a subunit of G(13) die around embryonic day 10 as the result of an angiogenic defect. On the other hand, the physiological role of G(12) is Still unclear. To address this issue, we generated Galpha(12)-deficient mice. in contrast to the Galpha(13)-deficient mice, Galpha(12)-deficient mice are viable, fertile, and do not show apparent abnormalities. However, Galpha(12). does not seem to be entirely redundant, because in the offspring generated from Galpha(12)+/-Galpha(13) intercrosses, at least one intact Galpha(12) allele is required for the survival of animals with only one Galpha(13) allele. In addition, Galpha(12) and Galpha(13) showed a difference in mediating cell migratory response to lysophosphatidic acid in embryonic fibroblast cells. Furthermore, mice lacking both Galpha(12) and Galpha(q) die in utero at about embryonic day 13. These data indicate that the Galpha(12)-mediated signaling pathway functionally interacts not only with the Galpha(13)- but also with the Galpha(q/11)-mediated signaling systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据