期刊
BRITISH JOURNAL OF CANCER
卷 87, 期 2, 页码 171-174出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6600432
关键词
gastric cancer; TNM-UICC classification; lymph node metastasis; stage migration; Will Rogers phenomenon
类别
The present study aimed at investigating whether in gastric cancer patients stage migration occurs with extension of lymphadenectomy, when node metastases are staged according to the new pN classification (UICC 1997). The Investigation involved 92 1 patients, who underwent RO gastric resection for gastric cancer between 1988 and 1998 in three different Italian centres: Verona (n=236), Forli (n=409), Siena (n=276). The relation among lymphadenectomy and pN category was assessed by Kendall's partial rank-order correlation coefficient, controlling for depth of tumour invasion. A direct evaluation of the Will Rogers phenomenon was accomplished In the Verona series, by comparing the number of positive nodes actually observed with the number of positive nodes which would have been retrieved by a less extended lymphadenectomy (D 1). The number of positive nodes increased remarkably with the enlargement of lymphadenectomy, especially In pT2 patients (from 2.2 +/- 3,9 in D1 to 3.9 +/- 5.0 in D3) and in pT3/p74 patients (from 5.1 +/- 5,9 in D I to 11.3 +/- 12.6 in D3). Non-parametric statistics highlighted a weak (Kendall's partial T=0.128) but significant (P < 0.001) correlation between pN category and extension of lymphadenectomy, In the direct analysis of the Verona series, 22 patients out of 230 (9.6%) migrated to a lower pN tier when ignoring positive nodes retrieved from the second and third level. This percentage increased to 39.1% (90 out of 230) when adopting the TNM 87 classification, In conclusion stage migration is of minor importance in gastric cancer patients, staged according to the new pN classification.(C) 2002 Cancer Research UK.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据