期刊
MOLECULAR BRAIN RESEARCH
卷 104, 期 1, 页码 103-109出版社
ELSEVIER
DOI: 10.1016/S0169-328X(02)00219-X
关键词
anxiety; communication box; diazepam binding inhibitor (DBI); mouse cerebral cortex; physical stress; psychological stress
Effects of conditioned emotional stimuli (CES), which induce psychological stress, on the expression of cerebral diazepam binding inhibitor (DbI) mRNA in mouse were examined using a communication box. Cerebral DBI mRNA expression significantly increased in a time-dependent manner after the application of CES. The maximal enhancement of DBI mRNA expression was observed 2 days after the application of CES, and this increase faded out over 7 days after the treatment. Flunitrazepam (1 mg/kg), an agonist for central benzodiazepine (BZD) receptors, completely abolished the CES-induced elevation of cerebral DBI contents and its mRNA expressions. These results indicate that cerebral DBI is enhanced by psychological stress, which is replated by central BZD receptors. (C) 2002 Elsevier Science B.V. All rights reserved.
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