期刊
CIRCULATION
卷 106, 期 3, 页码 289-291出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.CIR.0000025241.01418.4D
关键词
diet; fatty acids; risk factors
资金
- FIC NIH HHS [TW-05399] Funding Source: Medline
- NCRR NIH HHS [M0I-RR-00585] Funding Source: Medline
- NHLBI NIH HHS [HL-65176, HL-70602, HL-14388, R01 HL065176, HL-61560] Funding Source: Medline
Background-Leptin has been implicated in cardiovascular disease. A diet rich in fish has been associated with decreased cardiac and vascular risk. Methods and Results-We examined the relationship between diet and leptin in 2 related homogeneous African tribal populations of Tanzania. One tribe consumes freshwater fish as their main diet component (n=279), and the other tribe consumes a primarily vegetarian diet (n=329). In multivariate analysis, plasma leptin levels were associated with type of diet (F=14.3, P<0.001), independent of age, body mass index, body fat, alcohol consumption, or insulin. Both male (2.5 +/- 2 [fish diet] versus 11.2 +/- 2.4 [vegetarian diet] ng/mL, P=0.017) and female (5.0 +/- 1.9 [fish diet] versus 11.8 +/- 1.4 [vegetarian diet] ng/mL, P=0.007) fish eaters had lower plasma leptin levels than did their vegetable diet counterparts, even though body mass index values were virtually identical. Conclusions-A diet rich in fish is associated with lower plasma leptin, independent of body fat. These findings may have implications for understanding the reduced cardiovascular risk in subjects on a high-fish diet.
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