期刊
FEBS LETTERS
卷 523, 期 1-3, 页码 12-16出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(02)02904-6
关键词
roundabout; DUTT1; ROBO1; alternate splicing; bronchial epithelium; signal peptide
The mammalian homologue of the Drosophila axonal guidance receptor roundabout is expressed in a wide range of tissues. Here we show that alternative splicing of the Dutt1/Robo1 gene results in two mRNA transcripts with different signal peptides, which are differentially expressed throughout mouse embryogenesis. Since mice with a targeted deletion in the Dutt1/Robo1 gene have abnormal lung pathology, immunohistochemistry was used to identify the cellular expression pattern of Dutt1/Robo1 during lung development. Dutt1/Robo1 expression was widespread and diffuse in the lung at embryonic day 17.5 but became increasingly localised to the bronchial epithelium in newborn and adult mice. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
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