期刊
SCIENCE
卷 297, 期 5580, 页码 409-412出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1071632
关键词
-
资金
- NIAID NIH HHS [AI-40098] Funding Source: Medline
- NICHD NIH HHS [K12-HD00850] Funding Source: Medline
The mechanisms that control localization of marginal zone (MZ) B cells are poorly understood. Here we show that MZ B cells express elevated levels of the integrins LFA-1 (alphaLbeta2) and alpha4beta1 and that they bind to the ligands ICAM-1 and VCAM-1. These ligands are expressed within the MZ in a lymphotoxin-dependent manner. Combined inhibition of LFA-1 and alpha4beta1 causes a rapid and selective release of B cells from the MZ. Furthermore, lipopolysaccharide-triggered MZ B cell relocalization involves down-regulation of integrin-mediated adhesion. These studies identify key requirements for MZ B cell localization and establish a role for integrins in peripheral lymphoid tissue compartmentalization.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据