期刊
NEUROSCIENCE LETTERS
卷 327, 期 2, 页码 128-132出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(02)00399-3
关键词
glutamate; alcohol; channel; ligand-gated; chronic; hippocampus; receptor
资金
- NIGMS NIH HHS [R25 GM 60201-2] Funding Source: Medline
We have previously demonstrated that kainate receptors (KA-Rs) are acutely inhibited by ethanol (EtOH). Here we show that KA-Rs are also affected by long-term EtOH exposure. Whole-cell recordings of pharmacologically isolated KA-R-mediated currents in cultured hippocampal neurons revealed that exposure to 80 mM EtOH for 3 days followed by a 24 h withdrawal period increased KA-R current densities. Quantitative confocal microscopy showed that expression of GluR6/7 subunits increases after ethanol withdrawal in these neurons. Since KA-Rs control hippocampal excitability and seizure generation, we postulate that upregulation of these receptors may have a role in the pathophysiology of alcohol withdrawal syndrome. (C) 2002 Published by Elsevier Science Ireland Ltd.
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