期刊
TETRAHEDRON
卷 58, 期 30, 页码 6127-6133出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(02)00484-2
关键词
stereoselective Ugi four component reaction; chiral auxiliary; chiral amine component; amino thiocarbohydrate; alpha-amino acid derivatives
The Ugi four component reaction (U-4CR) offers a short and direct route for the synthesis of alpha-amino acid and peptide derivatives. With 1-amino-5-desoxy-5-thio-2,3,4-O-isobutanoyl-beta-D-xylopyranose as a chiral amine component excellent chemical yields and stereoselectivities are obtained. After the U-4CR the chiral auxiliary can be cleaved off selectively under mild conditions. The configuration of one of the products was confirmed by X-ray analysis. (C) 2002 Published by Elsevier Science Ltd.
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