Chromosome aberrations: past, present and future

Spontaneous and induced chromosome aberrations have been studied over more than a century. The resolution of detection of aberrations has depended on the improvement of available techniques. An overview on the major high lights in this area of research, from the time of solid staining to fluorescence in situ hybridization technique is presented in this review. (C) 2002 Elsevier Science B.V. All rights reserved.