期刊
NEUROSCIENCE LETTERS
卷 327, 期 3, 页码 203-207出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(02)00394-4
关键词
circadian rhythms; masking; entrainment; retinohypothalamic tract; photic; suprachiasmatic nucleus; period
Lighting cycles can influence the expression of daily activity rhythms in two ways: by entraining the circadian pacemaker that normally drives this rhythm, and by directly affecting the expression of activity itself, thereby 'masking' the influence of the pacemaker. We describe a California mouse (Peromyscus californicus) in which these processes are dissociated. Circadian rhythms of wheel-running activity were recorded continuously while the animal was housed in a standard light/dark cycle and in constant darkness. This animal expressed a normal circadian rhythm that failed to entrain to the light/dark cycle, but was completely masked during the light phase. This animal's phenotype appears to have a genetic basis, since the progeny of selective crosses of his descendants showed similar abnormalities. These mice are the first example of animals expressing apparently normal circadian rhythms that are not entrained by light, but that still show potent masking responses to light exposure. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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