期刊
NEUROPEDIATRICS
卷 33, 期 4, 页码 203-208出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2002-34497
关键词
aromatic L-amino acid decarboxylase deficiency neurotransmitters; hyperdopaminuria; L-dopa
Aromatic L-amino acid decarboxylase (AADC - E.C. 4.1.1.28) converts L-dopa to dopamine and 5-hydroxytryptophan to serotonin. Inherited deficiency of this enzyme leads to decreased brain levels of these neurotransmitters. Clinically this results in the development of a progressive neurometabolic disorder characterized by severe hypotonia, dystonic and choreoathetoid movements, oculogyric crises, and hypothermia from infancy. Here we describe the clinical, biochemical and molecular details of two affected brothers, one of whom, despite the lack of AADC, presented with hyperdopaminuria. In addition, we detail his reactions to treatment with dopaminergic agonists, monoamine oxidase inhibitors and pyridoxine.
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