期刊
PHARMACOLOGY
卷 65, 期 4, 页码 182-186出版社
KARGER
DOI: 10.1159/000064341
关键词
angiotensin-converting enzyme inhibition; quercetin; blood pressure; bradykinin; angiotensin I
Quercetin, one of the most widely distributed flavonoids in the plant kingdom, inhibits various enzymes. This study examined its inhibitory effect on the angiotensin-converting enzyme activity through the cardiovascular response to bradykinin and angiotensin I. Quercetin pretreatment (88.7 mumol/kg p.o., 45 min; 14.7 mumol/kg i.v., 5 min) significantly potentiated the hypotensive effect of bradykinin (10 nmol/kg i.v.). This association was significantly attenuated by an antagonist of the B2 receptor. In addition, the hypertensive response to angiotensin I (0.1 nmol/kg im.) was significantly reduced by quercetin pretreatment using the same parameters as before. These results suggest an inhibitory effect of quercetin on the angiotensin-converting enzyme activity, similar to that of captopril. Quercetin was equally effective when given orally or intravenously. Copyright (C) 2002 S. Karger AG, Basel.
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